The Trauma of Voices
and Body Mentalists.
Dr. Priscilla Slagle says on her website that the two supplements L-Glutamine and L-Tyrosine are the two Amino Acids she prescribes the most. She recommends L-Glutamine formed from another Amino acid called Glutamic Acid or Glutamate and is used for the treatment of Psychological traumas that mostly increase energy, improve mood trauma, concentration, focus and memory. According to Dr. Slagle Glutamine is often low in people with yeast overgrowth and is responsible for the 'Brain fog' that people often feel with Psychological mood swings.
Glutamine is an Amino acid in our bodies and is one of the building blocks of Protein. It is built in the bodies muscles hence exercise helping with mood swing Disorders such as Bipolar and traumatic Depression and Psychological trauma of Anxiety. In the body/brain barrier, it is supplied via the blood. It is said to help the gut and immune system both of which are involved in the body/brain barrier of the Vagus nerve in the Medulla Oblongata. The Parasympathetic and Sympathetic nerves are also part of the centre of the main area of the body/brain barrier.
The Sympathetic nerve along with the Glossopharyngeal nerve is a part of the thought and speech process involved in the Psychological trauma of Anxiety Disorders. This Glossopharyngeal Anxiety dysfunction is a part of the Psychological thought processes of the Vagus nerve as well during Confabulation of thoughtful Anxiety. Confabulation is delusional thoughts and visions.
Here also are the Parasympathetic nerve that affects Psychological traumas of Depression and low mood. That is a Rest and Digest function of the Psychosocial Peripheral Nervous System where the facial features conform to looking saddened. I call this one of the Facial Conformity Disorders. This is where Psychosocial affects the Core Identity (Self) in times of Psychological stress. And that causes mood swings and Depression, but also traumatic Parasympathetic Paranoia.
Glutamine provides fuel for the body and brain and is made of Nitrogenous Compounds and Carbon and supplies the cells in the body/brain barrier. Glutamine is vital for normal brain functions of the Central Nervous System (brain and spinal cord) and how it reacts in the blood and muscles to sublime Peripheral sensations that the body feels in the Endoderm, Mesoderm and Ectoderm tissue layers of the body’s meat. These relate to the 7 Chakras and the Foot Chakra (numbered zero) were thought exists as body language interpreted via the Vagus nerve and Glossopharyngeal nerve. These are centred on the Throat Chakra where the inner voice interprets thought to the inner ear via the Sympathetic system. Glutamine is available at most health food shops selling Nutraceutical (vitamins, minerals and herbs and oils) products.
Foods that contain glutamine include:
 fish and seafood
 milk
 yoghurt
 cheese
 eggs
 beans
 tofu
Glutamine supplements have been used for many ailments such as:
 stress
 anxiety
 Depression
 increase energy levels
 moodiness
 improving memory, focus and concentration
 attention deficit hyperactivity disorder (ADHD)
 irritability
 insomnia
A study on bone marrow transplant patients found that Glutamine allowed for the patients to gain a more vigorous, less angry and fewer fatigue symptoms. Fatigue and Lethargy go hand-in-hand with the Psychological trauma of Parasympathetic Depression simply because the face becomes slouched into a saddened look I know as a Psychological Facial Conformity Disorder.
‘Researchers at Boston Women’s Hospital, Massachusetts, gave healthy volunteers between 40 and 60 grams of glutamine a day for five days. Glutamine was found to be safe, and participants could solve problems better in performance tests. The amino acid supplement appears to work soon after starting it, and have a greater effect over time. The results of both studies were published in the Journal of Parenteral and Enteral Nutrition’.
If you do decide to medicate with L-Glutamine please consult your doctor immediately if you suffer any of these symptoms:
Extrahappiness.com says
• blood in the urine
• problems swallowing
• fainting
frequent and painful urination
• breathing problems such as rapid, shallow breathing or shortness of breath
Under the above list is another list of less common side effects. Drugs.com says that:
‘Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:’
Over 50 less common side effects follow including:
• body aches or pain
• sneezing
• skin problems such as blisters, coldness, hives, stinging or itching
• swelling of, for example, the legs, arms or face
• vomiting
WebMD says:
‘Glutamine is POSSIBLY SAFE for most adults and children when taken by mouth, but the potential side effects of glutamine are not known.
Adults should avoid using more than 40 grams of glutamine daily. Children, age [sic] 3 to 18, should not be given doses that are larger than 0.65 grams per kg of weight per day. Not enough is known about the safety of higher doses in children.’
According to the UMMC:
‘Glutamine appears to be safe in doses up to 14 g or higher per day.’
WebMD says glutamine can or might interact with:
 lactulose, which helps reduce ammonia in the body
 cancer medications
 anticonvulsants (medications to prevent seizures)
More information can be found here: http://extrahappiness.com/happiness/?p=3617
Mark Weatherall who suffers the Psychological trauma of Depression says:
Glutamine is literly like gold dust. For me it gives me more energy, clears mental fog & emotional stress, less craving for sugar, great for – before & after training for triathlons, less aches & pains. Totaly aids recovery & strengthens the immune system, mental calmness yet more alert. Stress relief and the list goes on! Oooo and great for my IBS aswell. Iv noticed a HELL of a difference when I havent been able to afford to buy it so now I make sure I can afford it! THE NUMBER ONE AMINO ACID and iv took them all in L-Form. DLPA comes in at 2nd place & 5HTP in 3rd place. If there is one side effect I could say it increases mania but id rather be manic than depressed any day!
The psychological trauma of the Parasympathetic nerve in Depression as a mental health disorder can leave you feeling like you've been hit by a car due to the Lethargy it causes. Some people think you can will yourself better. With the help of placebos mentioned in my two eBooks, this is certainly true: Buy the eBooks
Although the causes of Psychosocial Depression are not fully understood, biological, social and Psychological factors play there roles in forming this Facial Conformity Disorder due to Psychosocial (public) Peripheral (sublime) reactions that cause stresses to the body language and face.
While Parasympathetic nerve Psychological Depressive Disorders such as Bipolar Depression and Psychological trauma of clinical Depression, they are helped with counseling and medication. However, some choose alternative methods like Dr. Slagle to choose supplements such as L-Glutamine that in my estimation is far safer than some medications that are prescribed.
According to the University of Maryland Medical Center, Glutamine is the most abundant Amino acid in your body and has a number of biological functions. It aids in the removal of toxins and aids Chronic Inflammation of Psychological traumas via brain development. If you experience Psychological mood swings your body may need increases via L-Glutamine as it is easily depleted from the body/brain barrier by high levels of the stress hormone Cortisol.
Clinical Psychological Depression occurs in several forms. These conditions include:
1. Major Depressive Disorder.
2. Seasonal Affective Disorder (SAD).
3. Dysthymia.
4. Postpartum Depression.
5. Bipolar Depressive Disorder involved with mood swings.
According to NYU Langone Medical Center, symptoms of Psychological traumas of Depression differ from person to person. Some people suffer just a few symptoms of Psychological Parasympathetic nerve Depression, while some suffer a wide range of the many symptoms that Parasympathetic Depressive Disorder patients suffer. Symptoms include:
1. Feelings of low self-worth in Sympathetic nerve Anxious thoughts.
2. Mood swings into irritability.
3. Fatigue and Lethargy.
4. Lack of interest in activities that they once enjoyed.
5. Suicidal thoughts and Psychosocial gestures.
Researchers believe a number of factors are involved such as genetics, stressful life changes, drug and alcohol addiction, lack of social support from Psychosocial circumstances, medical illnesses and also changes in the neurochemistry of the body/brain barrier. The latter is where body language and facial structure cause body language a Facial Conformity Disorder via the Parasympathetic nerve reaction of Rest and Digest instead of its Peripheral body/brain neurochemistry of Ignorance to Psychosocial circumstances.
After Half a century where the first formulation of the Monoamine hypothesis was formed, there is now strong evidence that implies that long-term Neurochemical changes in the Medulla Oblongata and brain areas and circuits that mediate the complex Psychosocial cognitive-emotional behaviours. These represent the biological underpinnings of the Psychological trauma of Depression/Anxiety Disorders via an imbalance in the Parasympathetic and Sympathetic nerves, along with the Vagus nerve and Glossopharyngeal nerve. With a large number of clinical studies suggesting pathophysiology, it is now associated with the dysfunctions of the Glutamatergic system. Dysfunctions in the mechanisms regulating clearance and metabolism of Glutamate and cytoarchitectural/morphological of Chronic Inflammation are in a number of brain areas. And that is along with the negotiating of the Harmony of the Parasympathetic and Sympathetic nerves of the cognitive and Peripheral Psychosocial sublime emotional behaviours. Additionally, a plethora of data and knowledge gained from animal models have shown that different types of environmental Psychosocial stresses enhance Glutamate release/transmission in limbic/cortical areas and exert powerful Psychosocial autonomic structural effects, inducing a Dendritic remodeling, a reduction of Synaptic connections and possibly volumetric reductions resembling those that are observed in the depressive Disorders of patients. That is because a vast majority of the neurons and Synapses in the Parasympathetic and Sympathetic reaction areas and circuits use Glutamate as a Neurochemical in the body/brain barrier of the Psychosocial Autonomic and Peripheral Nervous System. It would be limiting to maintain that Glutamate is in some way ‘involved’ in Depressive/Anxiety Disorders; rather it should be seen as the Glutamatergic system as a primary mediator of the Psychological trauma of pathology of Chronic Inflammation. Also: a final pathway for the therapeutic action of Antidepressant medication and supplementation.
A paradigm shift from a Monoamine theory of Depression to a body/brain Plasticity, Arousal and Reward of Psychosocial body language hypothesis focused on Glutamate may represent a substantial advancement in the working theory that drives the research for new medicament and Cognitive Behavioral Therapy (CBT) via Sympathetic Disassociation and Parasympathetic Ignorance. And that is instead of Rest and Digest the Psychological trauma of Depressive Disorders and emotional mood swings. This is due to a lack of Fight or Flight from the Sympathetic nerve that causes the imbalance in this Harmonic area of the body/brain barrier. But despite multiple types of medication being available with Monoamine-based mechanisms of action such as L-Glutamine, there still remain a large number of patients that do not achieve a sustained remission from their depressive Disorder symptoms with Psychiatric drug treatment of experimental novel (Neologism) means! The need for more improved pharmacotherapy’s of treatment-resistant Depression means there is a large space for the development of new compounds with the natural novel mechanisms of Neurotransmitter action such as Glutamate transmission and its related pathways in the body/brain barrier of the Medulla Oblongata. This is where CBT is the main route of treatment towards the Psychosocial interaction of Neurochemicals in the Parasympathetic and Sympathetic nerves that happens in the Counselors negotiation. That negotiation causes a lifting of mood swings in the Psychosocial Peripheral actions on body language, Prosody (emotional tones) and a Facial Conformity Disorder that gets naturally lifted away from a Psychologically saddening trauma of a Depressive facial structure.
Monoamine (Amino acid) hypothesis has been experimented on for 50 years into Chronic Inflammation research of neuropsychiatric Disorders in particular Depressive/Anxiety Disorders, as well as production and experimentation of the vast array of therapeutic medications. With regards to Depression, it is theorized that pathology was due to or accompanied by reduced availability of Monoamines, particularly Serotonin and Noradrenaline of the Sympathetic nerve and that Antidepressants exerted their therapeutic action by increasing extracellular availability of Monoamines, particularly at the level of Synapses which control Neurochemical production. Its research was intrinsically tautological, in its main evidence and was based on the mechanism itself of Monoamine oxidase inhibitors and tricyclic Antidepressants, drugs that acutely increase the availability of Monoamines.
In a rhetoric fashioning over the years, a tautology is a logical argument constructed in such a way that generally repeats the same concept or assertion differently. However, it is the using of different phrasing or terminology that is the rhetoric, that the proposition as stated is logically irrefutable. Furthermore, it is the obscuring of the lack of evidence or valid reasoning supporting the stated conclusion. More experimental Neologism of Psychiatric Historical Insignificance.
In the following years and decades, the theories have had several modifications in the attempt to solve its inherent inconsistencies, the main one being the temporal discrepancy between the immediate effects of the drugs on Monoamines available (minutes, hours) and their therapeutic effects over several weeks. The basis of a ‘Glutamate theory’ over the natural supplement L-Glutamine can be traced back to the early part of the 1990’s where early findings showed that N-Methyl-D-Aspartate Receptor (NMDA-R) Antagonists possess an Antidepressant-like action. However more recently it has been theorized again and again and evolved, integrating research results from many different fields that includes intracellular signaling/mechanisms of gene expression, neurotrophic mechanisms, neurogenesis, Synaptic function and Plasticity, remodeling of neuronal cells/circuitry, into what has been referred to as a ‘Neuroplasticity theory’. Coincidentally, a corollary of these theories is that Neuroplasticity can be Biphasic: adaptive and also beneficial, such as by doing physical exercise and also taking Antidepressants. And that is versus maladaptive that has been observed in neuroimaging brain studies of Psychologically traumatized depressed patients or in animal models of traumatic stress and Psychological traumas of mood swing disorders. An additional corollary, as evidenced by a number of theoretical studies, is that maladaptive Plasticity in animal models that can at least partly be reversed by therapeutic treatments (CBT), including Antidepressant medications.
Although most of the Neuroplastic changes have been detected in the neurons and the body/brain circuitry of the predominant Glutamatergic Neurotransmitter system, we refer to a ‘Monoamine theory’, not a ‘Glutamate theory’ in the trauma of Depression and Psychological Anxiety. A vast majority of brain neurons and Synaptic connections are Glutamatergic, and Glutamate Synaptic transmission largely mediates both Psychosocial sublime Peripheral sensation to cognition and the resultant Neurochemical sublime feelings and emotion, two brain functions that seem to be inextricably linked together between the Parasympathetic and Sympathetic nerves. Moreover, compelling evidence from clinical studies suggests Glutamate transmission is abnormally regulated in a number of the limbic/cortical areas in the brain of Psychologically traumatized clinically depressed patients. Furthermore, increasing evidence suggests that the Glutamatergic signaling is associated with maladaptive changes in the structure and the function of Excitatory circuitry as an imbalance in the Parasympathetic Rest and Digest and a lack of Psychosocial Disassociation in the Excitatory Sympathetic nerve.
A whole wealth of data and knowledge from animal models of stress have shown that the different types of Psychosocial environmental stress enhance Glutamate release, reduce glial-mediated Glutamate cycling, and then alter Synapse connection transmission in limbic/cortical areas. Stress also induces powerful effects on structure and morphology in a rat's brain, inducing Dendritic remodeling, Synaptic spine reductions, glial loss, and also the possibility of volumetric reductions resembling those seen in the Psychological trauma of Parasympathetic nerve of the depressed patients. So, while it is well-established that Monoaminergic transmission has a primary role in the modulation of Psychosocial emotions and feelings and the resultant cognition of Psychological trauma of mood swing disorders, the time has come for us to recognize and posit that Excitatory transmission plays a key role in negotiation of the Sympathetic and Parasympathetic nerves and their Psychosocial interaction in the complex emotional and resultant cognitive changes associated with traumatic Depression and the Psychological trauma of Anxiety Disorders. In all likelihood, it also has representation in the actual final common pathway of any therapeutic treatments for Psychological Depression and other traumatic Anxiety Disorders. It should also be taken into research that while all Antidepressant agents available to patients have a Monoamine-based mechanism or at least a Monoamine-based Neurochemistry, there actually are no approved Antidepressant agents that directly target the Glutamatergic system of the body/brain barrier. Currently, only about 50–60% of the depressive Disorder patients respond to first-line Antidepressant treatment medicament therapies. And less than a third of the patients actually achieve a remission in the largest open-label study conducted so far to date. This means there is room for an improvement in the dealing of Psychiatric experimentation into Antidepressant medications. And that is, if non-Monoamine targets are taken into account and that there are new compounds developed that target directly Glutamate Neurotransmitter or related pathways such as the Nutraceutical supplemental called L-Glutamine.
Glutamate was not recognized as a neurotransmitter until the early 1980s, which is later than the monoaminergic transmitters. Glutamate is now accepted as the major Sympathetic nerve Excitatory neurotransmitter – by me - in the nervous system. Glutamate is the fast Excitatory transmission in the brain, but Aminobutyric acid (GABA), which is another amino acid Neurotransmitter and this mediates the vast majority of fast Parasympathetic nerve Inhibitory transmissions where the Ignorance kicks into Psychosocial Peripheral sublime interaction. It has been estimated that in the whole of the brain, there are approximately two to three hundred thousand Serotonergic neurons of the hundred billion total neurons which also negotiates the Psychological traumas of Sympathetic Anxiety and traumatic Parasympathetic Depression, but also Bipolar Disorder. Modern stereological methods have estimated that about 80% of neurons in the neocortex are from the effects of the Sympathetic Excitatory system and form 85% of all synaptic connections. While about 20% of the neurons are smooth and of the Parasympathetic Inhibitory affect and forming 15% of the synapses. These data indicate that Glutamate neurons and synapses outnumber all other Neurotransmitter systems in the brain via the Vagus nerve and its Medulla Oblongata affects of the Sympathetic and Parasympathetic nerves. The only exception of the GABAergic system comes to the body/brain barrier of the Vagus nerve leading to the Glossopharyngeal nerve and Psychological traumas of mood swings. In other words the brain, from the point of view of chemical Neurotransmission, is largely a Psychological Glutamatergic Sympathetic Excitatory action of negotiation, regulated by the smaller GABA reaction in the Parasympathetic Inhibitory component of Rest and Digest and the Inner Experience of thoughtfulness and is modulated by a much smaller number of neurons that release a variety of other neurotransmitters (including the Monoamines). It is well-known that Monoamines, by regulating fast Peripheral Sympathetic chemical neurotransmission, modulate all forms of brain function. This includes sleep/wakefulness, biological drive from negotiation activities mediated by the hypothalamus from the Glossopharyngeal nerve via the Inner thoughtfulness Experiences of the emotional/motivational trauma of Psychological mood swing. These activities are negotiated by limbic circuitry and value-based Rest and Digest Harmony behaviours in the neocortex that counteracts Fight or Flight from the Sympathetic nervous system. It is via the Inner Experience of Psychosocial Ignorance to Anxiousness. These changes to Sympathetic Excitatory transmission in the Central Nervous System of the body/brain interaction are with the Peripheral Nervous System of sublime interaction that is counterbalanced by the Parasympathetic Inhibitory component and that causes these functions in the Medulla Oblongata and its Glossopharyngeal nerve which leads to the Hypothalamus.
Increasing evidence that pathophysiological changes with the Amino acid Neurotransmitter systems are now being associated with the Psychosocial emotional mood and cognitive Psychological trauma of Sympathetic and Parasympathetic nerve imbalances of Anxiety dysfunctions. Reports of dysfunctions in the GABA content in patients with Psychosocial mood disorders, Glutamatergic dysfunctions have been demonstrated in the blood plasma, Cerebrospinal Fluid (CSF) and the Autonomic Nervous System of individuals afflicted with Psychological mood disorders such as traumatic clinical Depression Disorders, the Psychological trauma of Anxiety and the trauma of Bipolar Disorder.
Several studies have shown levels of higher Glutamate, and a Fashion Trend for decreased blood plasma Glutamine/Glutamate ratios in the blood of depressed patients. This is when compared to healthy people. Some other studies have provided some evidence that treatment with Antidepressant agents may decrease the plasma Glutamate levels in Psychologically traumatized Depressed patients. However, blood platelets possess a large level of Glutamate uptake in the system and are known to express the same amount of Glutamate transmitters that become present in the brain. A fact that Glutamate transport by human blood platelets appears as an indication of a variety of mental health illnesses that can be associated with the Glutamate impairment transmitters. This gives the suggestion that an alteration to blood platelet Glutamate uptake in Psychologically depressed patients takes place.
And yet it is seen as inconsistent with the theory and study of Bipolar Disorder patients in an emotional Psychological elation or mania dysfunction that have shown to have increased rates of Glutamate uptake in blood platelets towards the Sympathetic nerve. One study of depressed subjects has shown that blood platelet Glutamate levels to be numerically higher. However not significantly in traumatized depressed subjects compared to healthy people. There have been some attempts to directly compare the Central Nervous System tissue (meat) Glutamate content between mood disorder patients and the Norm of Society. Studies examining CSF from Psychological emotionally dysfunctional mood disorder patients are extremely limited.
One study has reported that reduced CSF Glutamate content in a mixture of patients with the Psychological trauma of major depressive and Bipolar Disorder and also an earlier study of CSF samples was unable to measure the Glutamate levels. It did, however, find that significantly higher CSF Glutamine concentrations in patients with the Psychological symptoms of major clinical depression disorder. The only study examining neurosurgical samples from chronically traumatized depressed patients failed to find any significance in the Frontal Cortex Glutamate concentrations. And yet a more recent post-mortem (autopsy) study of the frontal cortex showed a large increase in tissue Glutamate levels in individuals with Psychologically traumatizing major depressive and the trauma of Bipolar Disorders after controlling for post-mortem interval. This is then consistent with this examination of a recent analytic post-mortem Dorsolateral Prefrontal Cortex meat tissue that also revealed higher Glutamate levels in the trauma of Psychological Bipolar Disorder patients.
Ref:
http://extrahappiness.com/happiness/?p=3617
http://www.livestrong.com/article/477074-glutamine-Depression/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3205453/